Ringed sideroblasts are a reflection of iron-laden: a. ...

[kfurse]

Ringed sideroblasts are a reflection of iron-laden:
 
  a. Mitochondria
  b. Golgi complex
  c. Ribosomes
  d. Rough endoplasmic reticulum

Question 2

Which of the following would point to iron deficiency anemia as opposed to the ACI?
 
  a. Anemia
  b. High transferrin
  c. Low serum iron
  d. Elevated FEP

[miss.ashley]

Answer to Question 1

ANS: A
In the sideroblastic anemias, where ringed sideroblasts are present, plenty of iron is available to developing red cells. However, for one reason or another, the iron cannot be inserted into the protoporphyrin IX ring. Because this is the last step in heme synthesis, and it takes place in the mitochondria, the mitochondria become laden with iron. When these cells are stained with Prussian blue, the iron stains; mitochondria encircle the nucleus of the cell, so that what is seen is a ring of stained iron granules encircling the nucleus (hence called a ringed sideroblast).

Answer to Question 2

ANS: B
Transferrin is high in iron deficiency anemia but low in the ACI. All the other test results given are the same for both.

[kfurse]

TYSM

[mcarey591]

Thanks for the timely response, appreciate it