Answer to Question 1
ANS: A
Ringed sideroblasts are seen in the inherited forms of sideroblastic anemia but not in any of the other conditions listed.
Answer to Question 2
ANS: B
FEP increases because not enough adequate iron is available to insert into protoporphyrin IX. Transferrin receptors on the membrane of developing cells increase as the cells try to capture as much iron as possible (from what is bound to transferrin); these receptors are shed into plasma so that they increase (actually happens in stage 2). The number of sideroblasts will essentially be absent, because no excess iron is going to the developing red cells. The red cell count, as well as the hematocrit, is decreased.
A missense mutation that causes red blood cells to sickle in sickle-cell anemia.
Sickle cell anemia. The clinical manifestations of sickle cell anemia result from pathologic changes
Inherited DNA directs development of an organism.
Single nucleotide polymorphisms (SNPs) are organized into blocks that are inherited together. These
Over time, cells acquire mutations. Two independently acquired mutations in the same cell may be suf
Sickle Cell Anemia and Malaria