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Did you know?
In 1844, Charles Goodyear obtained the first patent for a rubber condom.
Did you know?
Nearly 31 million adults in America have a total cholesterol level that is more than 240 mg per dL.
Did you know?
Approximately one in four people diagnosed with diabetes will develop foot problems. Of these, about one-third will require lower extremity amputation.
Did you know?
Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.
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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.