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Author Question: What are three primary reasons that LSD, mescaline, and psilocybin are generally considered to ... (Read 63 times)

gonzo233

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on: Jun 22, 2018
What are three primary reasons that LSD, mescaline, and psilocybin are generally considered to belong to the same class of hallucinogen?
 
  What will be an ideal response?

Question 2

What are three neuro- or psycho-pharmacological features of the monoamine-related hallucinogens that distinguish them from the cannabinoid hallucinogens like delta-9-THC?
 
  What will be an ideal response?


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izzat

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Reply #1 on: Jun 22, 2018
Answer to Question 1

Their effects are all mediated through their actions on 5-HT receptors. Their effects are subjectively indistinguishable from one another at appropriate doses. They share a molecular structure with either dopamine or serotonin and have several methyl groups attached to them. Tolerance to their effects occurs fairly rapidly and there is profound cross-tolerance among them.

Answer to Question 2

Monoamine-related hallucinogens P/P/Hs act through 5-HT receptors whereas cannabinoids act on anandimide receptors. Monoamine-related hallucinogens are generally more potent in inducing hallucinatory and kaleidoscopic experiences than cannabinoids. Monoamine-related hallucinogens increase psychological and physiological signs of arousal, whereas cannabinoids tend to decrease these. Cannabinoids have a generalized fluidizing action on neuronal membranes that is not a property of Monoamine-related hallucinogens. Cannabinoids are much more lipid soluble than Monoamine-related hallucinogens and are stored in fat tissue for several weeks. Tolerance to the subjective effects of Monoamine-related hallucinogens occurs fairly rapidly, whereas they do not show as rapid a tolerance with cannabinoids. Chronic use of cannabinoids can result in mild physical dependence, whereas there is no evidence of this with Monoamine-related hallucinogens.


gonzo233

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Reply #2 on: Jun 22, 2018
Thank you!


izzat

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Reply #3 on: Jun 22, 2018
Happy to help


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