Answer to Question 1
Their effects are all mediated through their actions on 5-HT receptors. Their effects are subjectively indistinguishable from one another at appropriate doses. They share a molecular structure with either dopamine or serotonin and have several methyl groups attached to them. Tolerance to their effects occurs fairly rapidly and there is profound cross-tolerance among them.
Answer to Question 2
Monoamine-related hallucinogens P/P/Hs act through 5-HT receptors whereas cannabinoids act on anandimide receptors. Monoamine-related hallucinogens are generally more potent in inducing hallucinatory and kaleidoscopic experiences than cannabinoids. Monoamine-related hallucinogens increase psychological and physiological signs of arousal, whereas cannabinoids tend to decrease these. Cannabinoids have a generalized fluidizing action on neuronal membranes that is not a property of Monoamine-related hallucinogens. Cannabinoids are much more lipid soluble than Monoamine-related hallucinogens and are stored in fat tissue for several weeks. Tolerance to the subjective effects of Monoamine-related hallucinogens occurs fairly rapidly, whereas they do not show as rapid a tolerance with cannabinoids. Chronic use of cannabinoids can result in mild physical dependence, whereas there is no evidence of this with Monoamine-related hallucinogens.
The pattern of primary succession at Glacier Bay, Alaska.
The tolerance of male lions towards the cubs varies. They are, however, generally more likely to sha
The chemical structure of mescaline, derived from the peyote cactus
Primary factors affecting blood pressure
The Four Primary Drug-Receptor Families
Primary motor area of cerebral cortex