This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Why are two hits required to inactivate tumor-suppressor genes? (Read 29 times)

bcretired

  • Hero Member
  • *****
  • Posts: 525
on: Aug 28, 2021

Question 1

What aberrant change causes the abnormal growth in retinoblastoma?

◦ Proto-oncogenes are changed to oncogenes.
◦ The tumor-suppressor gene is turned off.
◦ Genetic amplification causes the growth.
◦ Chromosomes 9 and 21 are fused.

Question 2

Why are two “hits” required to inactivate tumor-suppressor genes?

◦ Each allele must be altered, and each person has two copies, or alleles, of each gene, one from each parent.
◦ The first hit stops tissue growth, and the second hit is needed to cause abnormal tissue growth.
◦ Tumor-suppressor genes are larger than proto-oncogenes, requiring two hits to affect carcinogenesis.
◦ The first hit is insufficient to cause enough damage to cause a mutation.
Pathophysiology: The Biologic Basis of Disease in Adults and Children ¦ McCance, Huether ¦ 8th Edition
Buy Test-Bank


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by bcretired on Aug 28, 2021

JYan

  • Sr. Member
  • ****
  • Posts: 331
Reply #1 on: Aug 28, 2021
Lorsum iprem. Lorsus sur ipci. Lorsem sur iprem. Lorsum sur ipdi, lorsem sur ipci. Lorsum sur iprium, valum sur ipci et, vala sur ipci. Lorsem sur ipci, lorsa sur iprem. Valus sur ipdi. Lorsus sur iprium nunc, valem sur iprium. Valem sur ipdi. Lorsa sur iprium. Lorsum sur iprium. Valem sur ipdi. Vala sur ipdi nunc, valem sur ipdi, valum sur ipdi, lorsem sur ipdi, vala sur ipdi. Valem sur iprem nunc, lorsa sur iprium. Valum sur ipdi et, lorsus sur ipci. Valem sur iprem. Valem sur ipci. Lorsa sur iprium. Lorsem sur ipci, valus sur iprem. Lorsem sur iprem nunc, valus sur iprium.
Answer Preview
Only 39% of students answer this correctly


bcretired

  • Member
  • Posts: 525
Reply 2 on: Aug 28, 2021
:D TYSM

tkempin

  • Member
  • Posts: 332
Reply 3 on: Yesterday
Gracias!

« previous next »
 

Did you know?

Adults are resistant to the bacterium that causes Botulism. These bacteria thrive in honey – therefore, honey should never be given to infants since their immune systems are not yet resistant.

Did you know?

Hypertension is a silent killer because it is deadly and has no significant early symptoms. The danger from hypertension is the extra load on the heart, which can lead to hypertensive heart disease and kidney damage. This occurs without any major symptoms until the high blood pressure becomes extreme. Regular blood pressure checks are an important method of catching hypertension before it can kill you.

Did you know?

If all the neurons in the human body were lined up, they would stretch more than 600 miles.

Did you know?

The first war in which wide-scale use of anesthetics occurred was the Civil War, and 80% of all wounds were in the extremities.

Did you know?

By definition, when a medication is administered intravenously, its bioavailability is 100%.

Genes May Interact Epistatically Genes May Interact Epistatically
The work of geneticists is valuable because genes play a role in virtually every aspect of ... The work of geneticists is valuable because genes play a role in virtually every aspect of ...
Partial map of disease genes on human chromosome 21 Partial map of disease genes on human chromosome 21
The structural genes of the lac operon are transcribed into a single polycistronic mRNA The structural genes of the lac operon are transcribed into a single polycistronic mRNA
Cross-regulatory interactions among gap genes Cross-regulatory interactions among gap genes
Evolution of genes derived from the cyanobacteria-like endosymbiont Evolution of genes derived from the cyanobacteria-like endosymbiont
Video: Random alignment at Metaphase I Animation

For a complete list of videos, visit our video library