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Author Question: DNA helicase inhibitors are well studied as potential drug targets. What would you expect to seeif ... (Read 12 times)

CORALGRILL2014

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on: Jan 12, 2022
DNA helicase inhibitors are well studied as potential drug targets. What would you expect to see 
if DNA helicase activity is inhibited?
◦ The replisome complex would not assemble on the oriC region.
◦ The DNA cannot bend, so hydrogen bonds in the 13-mer region of oriC remain intact.
◦ Helicase catalyzes ATP hydrolysis and DNA strands separation, so the helix cannot be unwound and strands will not separate.
◦ Helicase carries the SSB protein to the open region of DNA, so hydrolysis and strand separation will not occur.
◦ Helicase prevents reannealing of the separated strands, so strands would quickly reanneal and DNA replication cannot proceed.
Genetic Analysis: An Integrated Approach ¦ Sanders, Bowman ¦ 3rd Edition
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Marked as best answer by CORALGRILL2014 on Jan 12, 2022

ansleighelindsey

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Reply #1 on: Jan 12, 2022
Lorsum iprem. Lorsus sur ipci. Lorsem sur iprem. Lorsum sur ipdi, lorsem sur ipci. Lorsum sur iprium, valum sur ipci et, vala sur ipci. Lorsem sur ipci, lorsa sur iprem. Valus sur ipdi. Lorsus sur iprium nunc, valem sur iprium. Valem sur ipdi. Lorsa sur iprium. Lorsum sur iprium. Valem sur ipdi. Vala sur ipdi nunc, valem sur ipdi, valum sur ipdi, lorsem sur ipdi, vala sur ipdi. Valem sur iprem nunc, lorsa sur iprium. Valum sur ipdi et, lorsus sur ipci. Valem sur iprem. Valem sur ipci. Lorsa sur iprium. Lorsem sur ipci, valus sur iprem. Lorsem sur iprem nunc, valus sur iprium.
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CORALGRILL2014

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Reply 2 on: Jan 12, 2022
Thanks for the timely response, appreciate it

cdmart10

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Reply 3 on: Yesterday
Wow, this really help

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