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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
Though methadone is often used to treat dependency on other opioids, the drug itself can be abused. Crushing or snorting methadone can achieve the opiate "rush" desired by addicts. Improper use such as these can lead to a dangerous dependency on methadone. This drug now accounts for nearly one-third of opioid-related deaths.
More than 4.4billion prescriptions were dispensed within the United States in 2016.
Between 1999 and 2012, American adults with high total cholesterol decreased from 18.3% to 12.9%
In the United States, an estimated 50 million unnecessary antibiotics are prescribed for viral respiratory infections.