Clot-based mixing studies and Bethesda titers are used to test ...

[abarnes]

Clot-based mixing studies and Bethesda titers are used to test for:
 
  a. Vitamin K deficiency
  b. Inhibitors (antibodies) against coagulation factors
  c. DIC
  d. Hemophilia

Question 2

Which of the following would be appropriate initial testing for the siblings in Question 1?
 
  a. Fibrinogen, D-dimer, and platelet aggregation studies
  b. Factor VIII assay, liver function tests, and vitamin K level
  c. von Willebrand factor (VWF) antigen, Bethesda titer, and reptilase time
  d. Prothrombin time (PT), partial thromboplastin time (PTT), and platelet count

[covalentbond]

Answer to Question 1

ANS: B
An inhibitor against a coagulation protein is confirmed using clot-based mixing studies. The Bethesda titer is then performed to determine the concentration of the inhibitor.

Answer to Question 2

ANS: D
The initial hemostasis profile should consist of the PT, PTT, and platelet count.

[abarnes]

Excellent

[cici]

TYSM