What is the mechanism for ACI? a. Acute phase reactants impair ...

[laurencescou]

What is the mechanism for ACI?
 
  a. Acute phase reactants impair iron mobilization.
  b. Inflammation and infections slow heme development.
  c. Cytokines prevent iron incorporation into protoporphyrin.
  d. Bone marrow iron stores are depleted by acute phase reactants.

Question 2

What is most likely if a 10-month-old child fed only cow's milk has the following results?
 
   Serum iron decreased
   Total iron-binding capacity (TIBC) increased
   Ferritin decreased
 
  a. Lead poisoning
  b. Chronic disease
  c. Iron deficiency from increased need and inadequate diet
  d. Iron deficiency from chronic blood loss

[paavo]

Answer to Question 1

ANS: A
The acute phase reactants hepcidin, lactoferrin, and ferritin all contribute to impairing the mobilization of iron for erythropoiesis. Bone marrow iron stores are actually normal to increased in ACI.

Answer to Question 2

ANS: C
The iron studies all point to iron deficiency: low serum iron and ferritin, with an elevated TIBC. Cow's milk is a very poor source of iron, so the infant is not getting adequate iron to support an expanding erythron.

[laurencescou]

Correct answers!

[paavo]

Great! Please up vote