Answer to Question 1
Answer: Plasmacytoma: Localized tumor collection of plasma cells; can lead to multiple myeloma.
Multiple myeloma: Proliferating cell line: plasma cell; immunoglobulin produced: IgG.
MGUS: low level of monoclonal protein produced without the presence of an underlying neoplasm.
Waldenstrm's macroglobulinemia: Proliferating cell lines: lymphocytes, plasma cells, and lymphoid cells; immunoglobulin produced: IgM.
Neoplasm Features
multiple myeloma
M spike in serum or urine
Clonal plasma cells in bone marrow
Related organ or tissue damage (CRAB)
MGUS
M spike in serum or urine (<30g>Clonal plasma cells in bone marrow <10
No related organ or tissue damage
Plasmacytoma
Solitary collection of clonal plasma cells
May have M spike
No clonal plasma cells elsewhere in bone marrow
No related organ or tissue damage
Answer to Question 2
Correct Answer: B