Author Question: Identify the lab features of the following disorders: a. Plasmacytoma b. Multiple myeloma c. ... (Read 74 times)

mcmcdaniel · **on:** Jun 25, 2018

Identify the lab features of the following disorders:

a. Plasmacytoma
b. Multiple myeloma
c. MGUS
d. Waldenstrm's macroglobulinemia

What will be an ideal response?

Question 2

Which of the following agents promotes the development of non-Hodgkin lymphoma through mucosa-associated lymphoid tissue (MALT) infiltration?

a. BCL-2 translocation
b. Helicobacter pylori
c. Epstein-Barr virus
d. Ataxia telangiectasia

shewald78 · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

Answer: Plasmacytoma: Localized tumor collection of plasma cells; can lead to multiple myeloma.
Multiple myeloma: Proliferating cell line: plasma cell; immunoglobulin produced: IgG.
MGUS: low level of monoclonal protein produced without the presence of an underlying neoplasm.
Waldenstrm's macroglobulinemia: Proliferating cell lines: lymphocytes, plasma cells, and lymphoid cells; immunoglobulin produced: IgM.

Neoplasm Features

multiple myeloma
M spike in serum or urine
Clonal plasma cells in bone marrow
Related organ or tissue damage (CRAB)

MGUS
M spike in serum or urine (<30g>Clonal plasma cells in bone marrow <10
No related organ or tissue damage

Plasmacytoma
Solitary collection of clonal plasma cells
May have M spike
No clonal plasma cells elsewhere in bone marrow
No related organ or tissue damage

Answer to Question 2

Correct Answer: B