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Author Question: Identify the lab features of the following disorders: a. Plasmacytoma b. Multiple myeloma c. ... (Read 89 times)

mcmcdaniel

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on: Jun 25, 2018
Identify the lab features of the following disorders:
 
  a. Plasmacytoma
  b. Multiple myeloma
  c. MGUS
  d. Waldenstrm's macroglobulinemia
 
  What will be an ideal response?

Question 2

Which of the following agents promotes the development of non-Hodgkin lymphoma through mucosa-associated lymphoid tissue (MALT) infiltration?
 
  a. BCL-2 translocation
  b. Helicobacter pylori
  c. Epstein-Barr virus
  d. Ataxia telangiectasia


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shewald78

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Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: Plasmacytoma: Localized tumor collection of plasma cells; can lead to multiple myeloma.
Multiple myeloma: Proliferating cell line: plasma cell; immunoglobulin produced: IgG.
MGUS: low level of monoclonal protein produced without the presence of an underlying neoplasm.
Waldenstrm's macroglobulinemia: Proliferating cell lines: lymphocytes, plasma cells, and lymphoid cells; immunoglobulin produced: IgM.

Neoplasm Features

multiple myeloma
M spike in serum or urine
Clonal plasma cells in bone marrow
Related organ or tissue damage (CRAB)

MGUS
M spike in serum or urine (<30g>Clonal plasma cells in bone marrow <10
No related organ or tissue damage

Plasmacytoma
Solitary collection of clonal plasma cells
May have M spike
No clonal plasma cells elsewhere in bone marrow
No related organ or tissue damage

Answer to Question 2

Correct Answer: B


mcmcdaniel

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Reply 2 on: Jun 25, 2018
Great answer, keep it coming :)

xiazhe

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Reply 3 on: Yesterday
Wow, this really help

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