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In 1844, Charles Goodyear obtained the first patent for a rubber condom.
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Sildenafil (Viagra®) has two actions that may be of consequence in patients with heart disease. It can lower the blood pressure, and it can interact with nitrates. It should never be used in patients who are taking nitrates.
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Pope Sylvester II tried to introduce Arabic numbers into Europe between the years 999 and 1003, but their use did not catch on for a few more centuries, and Roman numerals continued to be the primary number system.
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Nearly 31 million adults in America have a total cholesterol level that is more than 240 mg per dL.
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In 1864, the first barbiturate (barbituric acid) was synthesized.