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Author Question: Which of the following are true regarding glucocorticoids? 1. They work through activation of ... (Read 15 times)

jazziefee

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on: Jul 16, 2018
Which of the following are true regarding glucocorticoids?
 
  1. They work through activation of intracellular receptors.
  2. Relief is immediate.
  3. Daily compliance is essential to controlling inflammation in asthma.
  4. They work in a similar fashion to adrenergic bronchodilators.
  a. 1 and 3 only
  b. 1, 3, and 4 only
  c. 2, 3, and 4 only
  d. 1, 2, 3, and 4

Question 2

Which of the following inhaled corticosteroids is a prodrug?
 
  a. Ciclesonide
  b. Flunisolide
  c. Budesonide
  d. Triamcinolone


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raenoj

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Reply #1 on: Jul 16, 2018
Answer to Question 1

ANS: A
Because steroid action involves modification of cell transcription, full antiinflammatory effects require hours to days. It is important for patients to understand that inhalation of an aerosolized steroid will not provide immediate relief as with an adrenergic bronchodilator. However, daily compliance with the inhaled medication is essential to controlling the inflammation of asthma.

Answer to Question 2

ANS: A
Ciclesonide, a prodrug, is given as an inactive compound and is converted to an active metabo-lite, desisobutyryl-ciclesonide (des-CIC), by intracellular enzymes.


jazziefee

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Reply 2 on: Jul 16, 2018
Thanks for the timely response, appreciate it

isabelt_18

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Reply 3 on: Yesterday
:D TYSM

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