The nurse is discussing the mechanism of action of omeprazole ...

[jlmhmf]

The nurse is discussing the mechanism of action of omeprazole (Prilosec) with a group of nursing students. Which statement by a student would best indicate understanding of the mechanism of action of omeprazole?
 
  a. The duration of action is short, because the drug has a short half-life.
  b. Absorption occurs in the stomach when the pH is greater than 5.
  c. It irreversibly inhibits the enzyme needed to produce stomach acid.
  d. The complete return of acid production occurs 24 hours after discontinuation.

Question 2

The nurse has provided education on factors that contribute to ulcer formation to her patient diagnosed with peptic ulcer disease (PUD). Which of the following statements by the patient indicates a need for further teaching?
 
  a. I guess I'll have to avoid coffee and cola from now on.
  b. I am surprised to learn that Helicobacter pylori infection can lead to ulcers.
  c. Instead of ibuprofen, I'll take acetaminophen for my arthritis.
  d. I'm going to ask my doctor to order a nicotine patch to help me quit smoking.

[Liddy]

Answer to Question 1

ANS: C
The mechanism of action of omeprazole is that it irreversibly inhibits the enzyme needed to produce stomach acid. Effects persist until new enzyme is synthesized, with partial recovery in 3 to 5 days.
Although the half-life of the drug is short, the effects persist long after the drug has been cleared from the body.
Absorption does not take place in the stomach. The medication is acid labile and would be destroyed in the gut without protection. It is enteric coated and designed to become activated in the alkaline environment of the duodenum.
Partial return of acid production occurs 3 to 5 days after the medication is stopped. Full recovery may take weeks.

Answer to Question 2

ANS: A
No convincing evidence shows that beverages containing caffeine (eg, coffee, tea, and cola) promote ulcer formation or interfere with recovery; this statement indicates a need for further teaching.
The most common cause of PUD is infection with H. pylori; no further teaching is necessary.
The second most common cause of PUD is the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is an NSAID, but acetaminophen is not; no further teaching is necessary.
Smoking delays ulcer healing and increases the risk of recurrence; no further teaching is necessary.

[jlmhmf]

TYSM

[pangili4]

Excellent