Answer to Question 1
Correct Answer: 3
Rationale 1: Lipid-soluble drugs do not have greater affinity for cardiac muscle tissue.
Rationale 2: Lipid-soluble drugs do not have greater affinity for the liver.
Rationale 3: Lipid-soluble drugs have a higher affinity for bone marrow, teeth, the eye, and adipose tissue.
Rationale 4: Lipid-soluble drugs do not have greater affinity for skeletal muscle tissue.
Global Rationale: Lipid-soluble drugs have a higher affinity for bone marrow, teeth, the eye, and adipose tissue. There is not greater affinity for cardiac muscle tissue, the liver, or in the skeletal muscle tissue.
Answer to Question 2
Correct Answer: 1
Rationale 1: The portion of the drug that is protein bound is not available to the tissues, but as it is released, it becomes a free drug; a drug that is highly protein-bound has a high percentage of bound or unavailable drug that will produce a longer duration of action.
Rationale 2: Drug excretion will not be accelerated.
Rationale 3: Metabolism of the drug will occur as the free drug portion becomes available.
Rationale 4: Onset of action of the drug will not be affected.
Global Rationale: The portion of the drug that is protein bound is not available to the tissues, but as it is released, it becomes a free drug; a drug that is highly protein bound has a high percentage of bound or unavailable drug that will produce a longer duration of action. Drug excretion will not be accelerated. Metabolism of the drug will occur as the free drug portion becomes available. Onset of action of the drug will not be affected.
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