Answer to Question 1
ANS: C
Drugs known to form complexes with the sequestrants include thiazide diuretics, digoxin, warfarin, and some antibiotics. To reduce the formation of sequestrant-drug complexes, oral medication should be administered either 1 hour before the sequestrant or 4 hours after. Further teaching is needed.
Warfarin should be taken 1 hour before or 4 hours after cholestyramine; this statement indicates that no further teaching is needed.
Adverse effects of Questran are limited to the gastrointestinal (GI) tract. Constipation, the principal complaint, can be minimized by increasing dietary fiber and fluids. This statement indicates that no further teaching is needed.
Digoxin should be taken 1 hour before or 4 hours after cholestyramine; this statement indicates that no further teaching is needed.
Answer to Question 2
ANS: C
When gemfibrozil and a statin are taken concurrently, the risk of myopathy is increased more than with either agent alone.
Hepatotoxicity, hypothyroidism, and heart failure, are not drug-to-drug interactions.