A patient is receiving aminophylline (Truphylline) intravenously. ...

[Collmarie]

A patient is receiving aminophylline (Truphylline) intravenously. Which change in assessment findings indicates to the nurse the possibility of drug toxicity?
 
  a. Heart rate increase from 72 to 82 beats per minute
  b. Hourly urine output decrease from 50 mL to 40 mL
  c. Pulse oximetry increase from 91 to 92
  d. Temperature increase from 99o F to 101o F

Question 2

A patient is receiving intravenous gentamicin. Which change in condition does the nurse report to the prescriber immediately?
 
  a. Temperature increase from 38 C to 39 C.
  b. Blood pressure decrease from 132/80 to 118/66.
  c. Total 24-hour urine output decrease from 2100 mL to 1100 mL.
  d. White blood cell (WBC) count decrease from 11,000/mm3 to 8500/mm3.

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Answer to Question 1

D
Methylxanthines, including aminophylline, stimulate the sympathetic nervous system. Signs and symptoms of toxicity include central nervous system irritability, restlessness, temperature eleva-tion, tremors, tachycardia, nausea and vomiting, palpitations, and dizziness.

Answer to Question 2

C
Gentamicin is an aminoglycoside antibacterial drug. These drugs are toxic to the kidneys (neph-rotoxic). A decrease of urine output by 1000 mL in a 24-hour time period is cause for concern about kidney function. The drug may need to be stopped or the dosage decreased.

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