Author Question: Neonates and infants have a decreased metabolism and excretion of drugs because of immaturity of ... (Read 38 times)

LCritchfi · **on:** Jul 23, 2018

Neonates and infants have a decreased metabolism and excretion of drugs because of immaturity of which organs?

a. Lungs and kidneys
b. Liver and kidneys
c. Spleen and pancreas
d. Gastrointestinal tract and kidneys

Question 2

Infants have decreased plasma protein-binding sites because of decreased plasma protein and albumin levels. With drugs that are highly protein bound, how should the drug dose for infants be different from that for adults?

a. It should be higher.
b. It should be lower.
c. It should be the same.
d. It varies by client.

matt95 · **Reply #1 on:** Jul 23, 2018

Answer to Question 1

ANS: B
The liver and kidneys are the primary organs for metabolism and excretion and are immature in infants.

Answer to Question 2

ANS: B
With fewer protein-binding sites, there is more active drug available. This requires a reduction in the dose for infants.