The nurse is reviewing a patient's medications prior to ...

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The nurse is reviewing a patient's medications prior to administration. The drug-drug interaction of most concern to the nurse is concurrent use of sildenafil (Viagra) and
 
  a. nitroglycerin.
  b. aspirin.
  c. thiazide diuretics.
  d. anticoagulants.

Question 2

The nurse is preparing to administer medications to a patient taking sucralfate (Carafate) and ciprofloxacin (Cipro). The drugs are ordered for 0900 . In what manner should the nurse proceed to administer the drugs?
 
  a. The nurse should administer the drugs with a full glass of water.
  b. The nurse should ask the prescriber to change the times to prevent concurrent administration.
  c. The nurse should administer the two drugs at same time with food.
  d. The nurse should administer the ciprofloxacin 15 minutes before the sucralfate.

[cdmart10]

Answer to Question 1

A
Concurrent use of sildenafil and nitrates or alpha blockers would most concern the nurse, because severe hypotension may occur.
Aspirin, thiazide diuretics, and anticoagulants have no known drug-drug interaction with silde-nafil.

Answer to Question 2

B
The nurse should ask the prescriber to change the times to prevent concurrent administration, because sucralfate may impede the absorption of ciprofloxacin. The interaction can be minimized by administering sucralfate at least 2 hours apart from ciprofloxacin.
Administration with a full glass of water does not address the implications of concurrent admin-istration.
A 2-hour interval is required between these drugs, and sucralfate needs to be taken on an empty stomach.
A 2-hour interval is required between these drugs.

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