Ketoconazole is used as an alternative to amphotericin B for less ...

[tingc95]

Ketoconazole is used as an alternative to amphotericin B for less severe systemic mycosis. Which are the primary reasons for choosing ketoconazole? (Select all that apply.)
 
  a. It can be given orally.
  b. It can be used safely in patients with he-patic dysfunction.
  c. It can be given once weekly rather than daily.
  d. It is effective for severe, acute infections.
  e. It is less toxic.

Question 2

A nurse is caring for a patient who has a superficial fungal infection and notes that the provider has ordered 200 mg of ketoconazole Nizoral 200 mg PO once daily. Which action by the nurse is correct?
 
  a. Administer the drug as ordered.
  b. Contact the provider to discuss twice daily dosing.
  c. Discuss a 400-mg daily drug regimen with the provider.
  d. Request an order for a different antifungal medication.

[gasdhashg]

Answer to Question 1

A, E
Ketoconazole is given instead of amphotericin B because it is less toxic and can be administered orally. Amphotericin B is administered intravenously. Ketoconazole is hepatotoxic; it is given daily. Ketoconazole is less useful for severe, acute infections.

Answer to Question 2

D
Because of the risk of serious and potentially fatal hepatic necrosis with oral ketoconazole, it is not recommended for use in treating superficial fungal infections. Another antifungal medication should be ordered.

[tingc95]

TY

[gasdhashg]

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