A nurse is teaching a patient about a drug that induces ...

[2125004343]

A nurse is teaching a patient about a drug that induces P-glycoprotein. The nurse will explain that this drug may cause which effect on other drugs?
 
  a. Decreased absorption in the intestines
  b. Decreased elimination through the kidneys
  c. Increased brain exposure
  d. Increased fetal absorption

Question 2

The nurse cares for patients who receive propofol extended Diprivan. What are important nursing considerations for these patients? (Select all that apply.)
 
  a. Ensuring that respiratory support equip-ment is readily available
  b. Maintaining the rate of intravenous infu-sion at 6 mg/kg/hr
  c. Refrigerating open vials of the drug up to 24 hours
  d. Stopping the infusion if a patient's CPK is greater than 5000 units/L
  e. Using a local anesthetic at the IV site prior to infusing the drug

[bobsmith]

Answer to Question 1

B
Drugs that induce PGP can increase drug export from cells of the intestinal epithelium into the intestinal lumen, thus decreasing absorption of the drug. PGP inducers also increase drug elimi-nation and decrease brain and fetal drug exposure.

Answer to Question 2

A, D, E
Propofol can cause profound respiratory depression. It has a relatively narrow therapeutic range and can cause death from respiratory arrest. Facilities for respiratory support should be imme-diately available. Propofol infusion syndrome may occur in patients receiving prolonged, high-dose infusion, and CPK levels should be monitored and the drug should be stopped if they are >5000 u/L. Propofol can cause transient pain at the IV site, which can be minimized by in-jecting IV lidocaine at the site just before injecting. The infusion rate should never be greater than 4 mg/kg/hr. There is a high risk of bacterial infection, so opened vials need to be discarded within 6 hours.

[2125004343]

Thank you!

[bobsmith]

Always glad to help...