What is the importance of correlating the dosage schedule with ...

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What is the importance of correlating the dosage schedule with cell cycle-specific drug therapy?
 
  a. Ongoing proliferation of neoplastic tissue
  b. The known cellular kinetics of the neoplasm
  c. The hormonal requirements of the patient
  d. The body's response in strengthening the immune system

Question 2

The cell cycle-specific agent vincristine sulphate (Oncovin) acts in which phase of the cell's life cycle?
 
  a. S phase
  b. Mitotic phase
  c. Phase G1
  d. Phase G0

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Answer to Question 1

ANS: B
Cell cycle-specific agent scheduling should be correlated with the known cellular kinetics of the particular type of neoplasm being treated. This type of drug is schedule dependent and selectively toxic when the cell is in a specific phase of growth. The object of chemotherapy is to stop the proliferation of neoplastic tissue. Hormones are only used in specific types of cancer and are not related to cell cycle specificity. Immunomodulators are used to enhance the body's response in strengthening the immune system.

Answer to Question 2

ANS: B
Vinca alkaloids block the formation of the mitotic spindle during mitosis, thus inhibiting cell division. The S phase is the stage of active synthesis of two sets of DNA. Phase G1 is considered a presynthetic phase in which the cell prepares for DNA synthesis by manufacturing necessary enzymes. G0 is the largest variable in the cell cycle and, during this resting phase, the cell is not actively replicating.

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TYSM

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