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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Most childhood vaccines are 90–99% effective in preventing disease. Side effects are rarely serious.
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To combat osteoporosis, changes in lifestyle and diet are recommended. At-risk patients should include 1,200 to 1,500 mg of calcium daily either via dietary means or with supplements.
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Bacteria have been found alive in a lake buried one half mile under ice in Antarctica.
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The horizontal fraction bar was introduced by the Arabs.