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Over time, chronic hepatitis B virus and hepatitis C virus infections can progress to advanced liver disease, liver failure, and hepatocellular carcinoma. Unlike other forms, more than 80% of hepatitis C infections become chronic and lead to liver disease. When combined with hepatitis B, hepatitis C now accounts for 75% percent of all cases of liver disease around the world. Liver failure caused by hepatitis C is now leading cause of liver transplants in the United States.
Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
The first oncogene was discovered in 1970 and was termed SRC (pronounced "SARK").
There are 20 feet of blood vessels in each square inch of human skin.
Famous people who died from poisoning or drug overdose include, Adolf Hitler, Socrates, Juan Ponce de Leon, Marilyn Monroe, Judy Garland, and John Belushi.
![Intradermal drug administration: (a) cross section of skin showing depth of needle insertion Source:](https://biology-forums.com/gallery/47/medium_46687_08_12_14_4_59_34_19526512.jpeg)
![Intramuscular drug administration: (c) the needle is inserted at a 90° angle: Source: Pearson Educat](https://biology-forums.com/gallery/47/medium_46687_08_12_14_5_05_08_195362384.jpeg)