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Author Question: Two individuals administered the same dose of a psychotropic drug for the very first time may ... (Read 83 times)

crobinson2013

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on: Jun 22, 2018
Two individuals administered the same dose of a psychotropic drug for the very first time may exhibit very different reactions to the drug. This is most likely due to
 
  a. context-specific tolerance
  b. pharmacodynamic tolerance
  c. dispositional or genetic tolerance
  d. conventional tolerance

Question 2

What are two pharmacodynamic actions of amphetamine upon acute administration?
 
  What will be an ideal response?


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bhavsar

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Reply #1 on: Jun 22, 2018
Answer to Question 1

c

Answer to Question 2

Amphetamine promotes reverse transport of monoamine neurotransmitters (dopamine, serotonin, norepinephrine) from axon terminals. This leads to an increase in the action potential induced release and the spontaneous leakage of monoamine neurotransmitters from axon terminals, which in turn leads to increased extracellular levels of monoamines and increased monoamine receptor activity. Amphetamine may also inhibit reuptake of monoamine neurotransmitters, and it mildly inhibits MAO activity intraneuronally.


crobinson2013

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Reply 2 on: Jun 22, 2018
Thanks for the timely response, appreciate it

vickyvicksss

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Reply 3 on: Yesterday
Gracias!

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