Question 1
What is the most common cause of insufficient erythropoiesis in children?
◦ Folic acid deficiency
◦ Iron deficiency
◦ Hemoglobin abnormality
◦ Erythrocyte abnormality
Question 2
How does hemolytic disease of the fetus and newborn (HDFN) cause acquired congenital hemolytic anemia?
◦ HDFN develops when hypoxia or dehydration causes the erythrocytes to change shapes, which are then recognized as foreign and removed from circulation.
◦ HDFN is an alloimmune disease in which the mother’s immune system produces antibodies against fetal erythrocytes, which are recognized as foreign and removed from circulation.
◦ HDFN develops when the polycythemia present in fetal life continues after birth, causing the excessive number of erythrocytes to be removed from circulation.
◦ HDFN is an autoimmune disease in which the fetus’s immune system produces antibodies against fetal erythrocytes, which are recognized as foreign and removed from circulation.
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