Question 1
In immunoglobulin G (IgG) nephropathies such as glomerulonephritis, IgG is deposited in which location?
◦ Juxtamedullary nephrons
◦ Glomerulus basement membranes
◦ Mesangium of the glomerular capillaries
◦ Parietal epithelium
Question 2
What is the pathophysiologic process responsible for the autoimmune disorder of hemolytic-uremic syndrome (HUS)?
◦ Immunoglobulin A (IgA) coats erythrocytes that are destroyed by the spleen, and remnants are excreted through the kidneys.
◦ Verotoxin from
Escherichia coli is absorbed from the intestines and damages erythrocytes and endothelial cells.
◦ Endotoxins from
E. coli block the erythropoietin produced by the kidneys, which reduces the number of erythrocytes produced by the bone marrow.
◦ Failure of the nephron to filter urea increases the blood urea nitrogen, which binds to erythrocytes that are subsequently destroyed by the spleen.
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