Explain why infections with Clostridium perfringens lead to ...

[itsmyluck]

Explain why infections with Clostridium perfringens lead to hemolysis of the RBCs.
 
  What will be an ideal response?

Question 2

Describe the mechanism that causes the production of schistocytes in microangiopathic hemolytic anemia.
 
  What will be an ideal response?

[choc0chan]

Answer to Question 1

Answer: C. perfringens releases an endotoxin (alpha toxin) that alters the sphingomyelin and lecithin in the erythrocyte membrane. This alters the integrity of the erythrocyte membrane and leads to hemolysis.

Answer to Question 2

Answer: Erythrocyte damage is usually the result of some type of physical damage resulting in fragmentation of the membrane. As the damage occurs, the erythrocyte membrane is sliced open and then seals itself. As it seals, abnormal shapes formed, referred to as schistocytes, can form. In MAHA, the damage to the endothelial lining of blood vessels can result in deposits of fibrin within the vessels. As erythrocytes pass thru the fibrin web, the membranes are fragmented.