Author Question: Explain why infections with Clostridium perfringens lead to hemolysis of the RBCs. What will be ... (Read 83 times)

itsmyluck

  • Hero Member
  • *****
  • Posts: 546
Explain why infections with Clostridium perfringens lead to hemolysis of the RBCs.
 
  What will be an ideal response?

Question 2

Describe the mechanism that causes the production of schistocytes in microangiopathic hemolytic anemia.
 
  What will be an ideal response?



choc0chan

  • Sr. Member
  • ****
  • Posts: 362
Answer to Question 1

Answer: C. perfringens releases an endotoxin (alpha toxin) that alters the sphingomyelin and lecithin in the erythrocyte membrane. This alters the integrity of the erythrocyte membrane and leads to hemolysis.

Answer to Question 2

Answer: Erythrocyte damage is usually the result of some type of physical damage resulting in fragmentation of the membrane. As the damage occurs, the erythrocyte membrane is sliced open and then seals itself. As it seals, abnormal shapes formed, referred to as schistocytes, can form. In MAHA, the damage to the endothelial lining of blood vessels can result in deposits of fibrin within the vessels. As erythrocytes pass thru the fibrin web, the membranes are fragmented.



Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
 

Did you know?

Only one in 10 cancer deaths is caused by the primary tumor. The vast majority of cancer mortality is caused by cells breaking away from the main tumor and metastasizing to other parts of the body, such as the brain, bones, or liver.

Did you know?

People often find it difficult to accept the idea that bacteria can be beneficial and improve health. Lactic acid bacteria are good, and when eaten, these bacteria improve health and increase longevity. These bacteria included in foods such as yogurt.

Did you know?

Immunoglobulin injections may give short-term protection against, or reduce severity of certain diseases. They help people who have an inherited problem making their own antibodies, or those who are having certain types of cancer treatments.

Did you know?

Women are 50% to 75% more likely than men to experience an adverse drug reaction.

Did you know?

Though newer “smart” infusion pumps are increasingly becoming more sophisticated, they cannot prevent all programming and administration errors. Health care professionals that use smart infusion pumps must still practice the rights of medication administration and have other professionals double-check all high-risk infusions.

For a complete list of videos, visit our video library