Answer to Question 1
Seroconversion means there is a change in antibody status from negative to positive (ie, absent to present).
Antibodies detected in the patient's blood that are directed against a protein found on the surface of the hepatitis B virus indicate the patient is recovering or recovered from an infection with hepatitis B virus.
Answer to Question 2
A serological diagnosis is one that is determined by measuring antigen and/or antibody levels in the serum. The actual infectious agent is not measured, but rather the immune system's response to an infectious agent is detected, indicating the patient is currently infected, convalescing, or recovered.
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