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Aspirin is the most widely used drug in the world. It has even been recognized as such by the Guinness Book of World Records.
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To prove that stomach ulcers were caused by bacteria and not by stress, a researcher consumed an entire laboratory beaker full of bacterial culture. After this, he did indeed develop stomach ulcers, and won the Nobel Prize for his discovery.
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There are 60,000 miles of blood vessels in every adult human.
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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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Lower drug doses for elderly patients should be used first, with titrations of the dose as tolerated to prevent unwanted drug-related pharmacodynamic effects.