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Author Question: What is the primary function of the P450 enzymes in the liver? What will be an ideal ... (Read 135 times)

renzo156

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on: Jun 22, 2018
What is the primary function of the P450 enzymes in the liver?
 
  What will be an ideal response?

Question 2

Mathematically, how does one determine a drug's therapeutic index?
 
  What will be an ideal response?


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Jane

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Reply #1 on: Jun 22, 2018
Answer to Question 1

To metabolize toxic chemicals introduced into the body into less active/toxic molecules or into more water-soluble (ionized) molecules that can be excreted more rapidly from the body via the kidneys (although sometimes the metabolites produced may actually become more active or toxic than the parent compound)

Answer to Question 2

First determine the dose that produces a specified or desired effect in 50 of a sample of individuals/animals (ED50) and the dose that produces lethality in 50 of a similar sample of individuals/animals (LD50), and then divide the LD50 by the ED50.


renzo156

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Reply #2 on: Jun 22, 2018
Thank you


Jane

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Reply #3 on: Jun 22, 2018
No problem :)


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