Answer to Question 1
Correct Answer: 1,2
Rationale 1: First-dose phenomenon is the onset of orthostatic hypotension when beginning or changing the dose of a beta-adrenergic antagonist.
Rationale 2: Taking the medication at bedtime will reduce the onset of first-dose phenomenon.
Rationale 3: Although this reaction may dissipate in time, this statement does not explain the cause of the client's symptoms.
Rationale 4: The client is experiencing first-dose phenomenon because of the increase in the dosage.
Rationale 5: The client was taking the prescribed increased dose of the medication.
Global Rationale: First-dose phenomenon is the onset of orthostatic hypotension when beginning or changing the dose of a beta-adrenergic antagonist. Taking the medication at bedtime will reduce the onset of first-dose phenomenon. Although this reaction may dissipate in time, this statement does not explain the cause of the client's symptoms. The symptoms the client is experiencing are consistent with the first-dose phenomenon of the prescribed medication dose.
Answer to Question 2
Correct Answer: 1,2,3,4
Rationale 1: Diminished myocardial contractility decreases cardiac output.
Rationale 2: The release of renin by the kidney, which is normally stimulated by catecholamines, is prevented.
Rationale 3: The nonselective adrenergic antagonists block alpha1-adrenergic receptors, relaxing arteriolar smooth muscle.
Rationale 4: Central actions reduce sympathetic output from the vasomotor center in the brain.
Rationale 5: Nonselective beta blockers may increase serum triglycerides and decrease high-density lipoproteins.
Global Rationale: Diminished myocardial contractility decreases cardiac output. The release of renin by the kidney, which is normally stimulated by catecholamines, is prevented. The nonselective adrenergic antagonists block alpha1-adrenergic receptors, relaxing arteriolar smooth muscle. Central actions reduce sympathetic output from the vasomotor center in the brain. Nonselective beta blockers may increase serum triglycerides and decrease high-density lipoproteins.