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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
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Asthma cases in Americans are about 75% higher today than they were in 1980.
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Increased intake of vitamin D has been shown to reduce fractures up to 25% in older people.
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Human kidneys will clean about 1 million gallons of blood in an average lifetime.
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In ancient Rome, many of the richer people in the population had lead-induced gout. The reason for this is unclear. Lead poisoning has also been linked to madness.